Focusing on the areas of diagnostic Nuclear Medicine and Radiation Oncology Imaging, this book provides a comprehensive treatment of the use of MATLAB in clinical Medical Physics, in Nuclear Medicine. It is an invaluable guide for medical physicists and researchers, in addition to postgraduates in medical physics or biomedical engineering, preparing for a career in the field.
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This book gathers a collection of cases with challenging diagnoses, in which nuclear medicine examinations have been particularly helpful in terms of the final diagnosis or follow-up. The cases presented chiefly involve patients with neurodegenerative disorders, epilepsy and brain tumors. The book is intended for nuclear medicine specialists as well as clinicians, offering essential guidance on the interpretation of neurology cases in the clinical setting, particularly with regard to correctly interpreting diagnostic imaging procedures. The authors were selected from the members of the Neuroimaging Committee of the EANM and have extensive experience as clinicians and teachers within the Nuclear Medicine Community.
Abstract:Immunotherapy by using immune checkpoint inhibitors is a revolutionary development in oncology. Medical imaging is also impacted by this new therapy, particularly nuclear medicine imaging (also called radionuclide imaging), which uses radioactive tracers to visualize metabolic functions. Our aim was to review the current applications of nuclear medicine imaging in immunotherapy, along with their limitations, and the perspectives offered by this imaging modality. Method: Articles describing the use of radionuclide imaging in immunotherapy were researched using PubMed by April 2019 and analyzed. Results: More than 5000 articles were analyzed, and nearly 100 of them were retained. Radionuclide imaging, notably 18F-FDG PET/CT, already has a major role in many cancers for pre-therapeutic and therapeutic evaluation, diagnoses of adverse effects, called immune-related adverse events (IrAE), and end-of-treatment evaluations. However, these current applications can be hindered by immunotherapy, notably due to atypical response patterns such as pseudoprogression, which is defined as an increase in the size of lesions, or the visualization of new lesions, followed by a response, and hyperprogression, which is an accelerated tumor growth rate after starting treatment. To overcome these difficulties, new opportunities are offered, particularly therapeutic evaluation criteria adapted to immunotherapy and immuno-PET allowing us to predict responses to immunotherapy. Moreover, some new technological solutions are also promising, such as radiomic analyses and body composition on associated anatomical images. However, more research has to be done, notably for the diagnosis of hyperprogression and pseudoprogression. Conclusion: Immunotherapy, by its major impact on cancer and by the new patterns generated on images, is revolutionary in the field of medical images. Nuclear medicine imaging is already established and will be able to help meet new challenges through its plasticity.Keywords: positron emission tomography; programmed cell death 1 receptor; diagnostic imaging; CTLA-4 Antigen; Immunotherapy; Adoptive; radioactive tracers; radionuclide imaging; CD8-Positive T-Lymphocytes
The Nuclear Medicine Certificate is an advanced certificate and requires entering students to have already completed prior college Health Sciences and/or science coursework. Because this program is an advanced certificate, it is strongly recommended that interested students meet with a Nuclear Medicine Technology program faculty and/or Health Sciences advisor early in their matriculation at Midlands Technical College. Nuclear medicine technologists are trained in the safe handling and application of radioactive materials for diagnostic and therapeutic procedures in the medical field. The applied skills of nuclear medicine technologists complement nuclear medicine physicians by providing clinical information pertinent to patient diagnosis and treatment.
Nuclear medicine technologists are trained in the safe handling and application of radioactive materials for diagnostic and therapeutic procedures in the medical field. The applied skills of nuclear medicine technologists complement nuclear medicine physicians by providing clinical information pertinent to patient diagnosis and treatment.
Dr. Iagaru is a Professor of Radiology - Nuclear Medicine and the Chief of the Division of Nuclear Medicine and Molecular Imaging at Stanford University Medical Center. He completed medical school at Carol Davila University of Medicine, Bucharest, Romania, and an internship at Drexel University College of Medicine, Graduate Hospital, in the Department of Medicine in Philadelphia. He began his residency at the University of Southern California (USC) Keck School of Medicine, Los Angeles, in the Division of Nuclear Medicine. Dr. Iagaru finished his residency and completed a PET/CT fellowship at Stanford University's School of Medicine in the Division of Nuclear Medicine. His research interests include PET/MRI and PET/CT for early cancer detection; clinical translation of novel PET radiopharmaceuticals; peptide-based diagnostic imaging and therapy; targeted radionuclide therapy.Since joining the faculty at Stanford in 2007, Dr. Iagaru has received several awards including the Society of Nuclear Medicine (SNM) 2009 Image of the Year Award; AuntMinnie 2016 Best Radiology Image, American College of Nuclear Medicine (ACNM) Mid-Winter Conference 2010 Best Essay Award; 2009, 2014 and 2015 Western Regional SNM Scientist Award; 2011 SNM Nuclear Oncology Council Young Investigator Award; the 2020 Sanjiv Sam Gambhir Distinguished Scientist Award, Western Regional SNM and the 2022 Sanjiv Sam Gambhir Trailblazer Award, SNMMI. Dr. Iagaru published more than 210 papers in peer-reviewed journals, as well as 9 book chapters and 1 book.
The study will be conducted as an open label, single-dose, explorative study with patients with histologically proven cancer and, preferably, tumor positive lesions in previously performed nuclear medicine imaging examinations. The investigational drug will be given as a single administration in a dose of
The nuclear medicine division at Jackson Memorial Hospital has 6 gamma cameras and a state of the art PET/CT System. Both diagnostic and therapeutic nuclear medicine procedures are offered. Our team has vast experience and a wealth of knowledge in all aspects of diagnostic imaging and therapeutic services. The department is accredited by the American College of Radiology.
You may resume normal activities after most Nuclear Medicine procedures.
You will be given specific instructions to follow after certain therapy procedures.
The results of your nuclear medicine scan will be made available to the prescribing physician.
Prof. Dr. Lückerath is a biomedical scientist with a focus on experimental and translational theranostics. A priority of her research is on delivering new insights into tumour biology and its relationship and relevance to functional imaging and biomarker-driven treatments in nuclear medicine. Prof. Dr. Lückerath obtained her PhD at the Institute for Tumor Biology and Experimental Therapy (Georg-Speyer-Haus, Germany). She served as head of the research group Experimental Oncology in Nuclear Medicine at the University of Würzurg (Germany), and of the pre-clinical Nuclear Medicine team at the University of California Los Angeles (USA; with Johannes Czernin), before transferring to University Hospital Essen in March 2021 as professor of Preclinical Theranostics.
So far, he did spend 25 years in the Nuclear Medicine environment and he published several review articles as well as a general audience book on that topic translated in French, English and Spanish. His main interest is now focused on the long-term evolution of nuclear medicine through the identification and evaluation of industrial, regulatory, and economic constraints with expert reports published yearly since 2014 through the partnership MEDraysintell. The 9th edition of this report (3,200+ pages) was published in September 2023. 2ff7e9595c
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